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KMID : 0355219920170020099
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Journal of Korean Academy Oral Medicine
1992 Volume.17 No. 2 p.99 ~ p.108
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A Study on the Polymorphisms in Parotid Salivary Proteins of the Patients with Diabetes mellitus
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Abstract
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The purpose of this study was to evaluate the polymorphisms in parotid salivary proteins of the patients with diabetes mellitus.
Saliva from the parotid glands was collected from 94 healthy Korean adults who were live in Kwang-ju and from 33 diabetes mellitus patients who had more than 140mg/dl of fasting-blood sugar for one week.
Diabetes mellitus patient group was subdivided to insulin dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus(NIDDM).
In the saliva collected from the parotid glands, parotid acidic protein(Pa), proline-rich protein)Pr) and double band protein(Db) were analyzed to evaluate the distribution of phenotype using alkaline slab polyacrylamide gel electrophoresis.
@ES Results were follows;
@EN 1. The parotid acidic protein (Pa) was found more frequently in the diabetes mellitus patient group than in the control group, but the difference was not statistically significant.
2. The Pr(1-2) type was found more frequently in the control group, but the Pr(1-1) and Pr(2-2) type were found more frequently in the diabetes mellitus patient group and the difference of phenotypic distribution was statistically significant
between
the two groups.(p<0.05).
3. The parotid acidic protein(Pa) and Pr(1-2) type were found more frequently in the noninsulin dependent diabetes melltus(NIDDM) patients than in the insulin dependent diabetes mellitus patients, though the difference was not statistically
significant.
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KEYWORD
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